The AV40's have a VERY blue ring around volume that might be annoying to you if you leave them on in the dark. The Klipsch provide the ability to fill a room with sound very nicely for movie watching or throwing a party.

I would also add that the AV40's are much more directional than the Klipsch - fine for me listening to music while seated at the computer. However, Klipsch have the benefit of producing a much more aggressive base profile due to the dedicated base module, but I don't miss it. You can hear the lack of detail in poor quality audio compared to high definition sound. Where the Klipsch provided me with excellent sound reproduction, the crisp sound of my AV40's is amazing. I know this comparison isn't exactly what you are looking for, but I hope it helps. I originally had the Klipsch setup, but I grew tired of the wires all over the place and went looking for something more compact (I'm a college student.who moves). I own both the M-Audio AV40's and a set of Klipsch Ultra 5.1's.

Klipsch promedia 2.1 no sound